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    2022-09-27 01:38:24÷˹ҽѧ
    ʾܵʱͻᷢӲҸϸ𽥱̺֯ȡ¸޷һЩչΪӲĻտҪиֲ

    Ǿƾ֬Ըβ (NAFLD) һֳļָٺȾƻ򲻺ȾƵ˵ĸл۹֬һ鼲NAFLD ʽΪ֬Ρ֬У֬ڸϸС NAFLD ߿ɷչɷǾƾ֬Ը (NASH) NASH У֬ѻϸ֢Ͳ̶ͬȵİ̺йأܵصĸγɺ͸ӲܵʱͻᷢӲҸϸ𽥱̺֯ȡ¸޷һЩչΪӲĻտҪиֲ

    NAFLD û֢״Ҽָܻͯʹ֢״ڸϲʱƣ͡ǣӦʹƣ͵ԭʱܻ΢һЩְܻͯƬ״ɫƤڼƤھҸ

    ݹƣй֮һȺܵ༲ţҸΣHBVΣHCVӲΰǾƾ֬ΣNAFLDƾԸβALDҩԸˣDILIʹøβΪйʺʵҪӰ֮һǰJOURNAL OF HEPATOLOGYĹйβоʾйж700ˣ0.5%ˣиӲлԸβĻҲܸߣУNAFLDӰ1.73-3.38ˡ

    оʾйNAFLDвѧоУкũNAFLDʷֱΪ21.83%20.43%йNAFLDĻʴ200317%201222.4%24.13%ŷޣ23.71%ձ25%൱

    ŶڸüоԽԽ֤ݱNAFLDȫӰ죬2򲡡ѪܼijЩ͵ĸйء

    ڣThe Lancet Gastroenterology & HepatologyϸNAFLDһֶϵͳвѧ֤ݣIJѧƣԼⲢ֢Ϻ͹

    оУ16۲оԼ3.4ˣ36%NAFLDƽý7һͷڷNAFLDȺNAFLDѪܼͷԣ64%NAFLDԽأѪ¼Խߡ

    33оdz50壨30.8%NAFLDƽý5һͷNAFLDߵ2򲡵ķǷNAFLDȺ2.19ڸάس̶ӵNAFLDУַոߣﵽ3.42

    Dzͬҳ120˵ĴͷλʱΪ9.7ڼ䣬NAFLDߵ3ڣΪeGFR<60mL/min/1.73m2ǷNAFLDȺ1.43άNAFLDУֳڷոǸߴ2.90

    Լ9.1᳦ܽɸ֢״ˣҪᣩͷ֣NAFLDֱ߽28%-61%ֱ56%-204%ֱֱ·շֱ42%208%ַߣNAFLDߵ䡢Ա״ָ2򲡻лۺ޹ء

    ⣬50%ϵNAFLD߷лۺˣӺϲķգ2򲡡ѪܼЩƵлءNAFLD߶ԣ౾Ľ״2򲡺ѪܼԼDZڵĶΣأڴлۺУҲŹؼã¶ӲѪ֬쳣ѪѹߡѪ쳣2򲡺ԷֵȵӰ졣

    ʵϣ2017꣬׶εɽѧɽҽѧŶӾڡಡѧ־NAFLDлۺȵصֿ򲡣׻ѪܼйءʱоԱNAFLD͸ϸHCCϵһİֱٰ֢йء

    عо20049200512ڼܽĽ26000˵ļ¼ڼһûа֢ϣƽ7.5ꡣ

    ʾо872133.6ĸ屻ΪNAFLDİ֢ʱȷNAFLD32һ˿ͳѧʹлصݣض֢شվֳˡԣNAFLD߷HCCĿ16.73չΪ᳦ֱĿԵչΪٰĿԼŮԵ

    оݻʾάָ꣬NAFLDά֣NFSFIB-4ֵĸ߷Ҳа֢رHCCĸ߷ءNFSʾ87FIB-4ӷ74ЩرΪ֢HCCԤָꡣ

    NAFLDӣôʲôԤ

    5£ͬǷHepatology־ϵһоſ˴ѧоԱ֣ѪǿܹԤNAFLD/NASHиϸ͸άس̶ȣŻѪǿƿǸıNASHصάչյһֶΡ

    оöſNAFLDٴݿ⣬˾֤NAFLD/NASHn=713ߣԼͨǻѪ쵰ףHbA1cⶨѪǿƵĹ

    о֣ϸߵƽHbA1c߷ּĸ֬Ժ͸ϸ䡢ǸСҶ֢йءƽHbA1cÿ1%άּӵļʾͻ15%OR 1.15 95% CI 1.01 1.31õѪǿȣжȿϸ䣨OR 1.74 95% CI 1.01 3.01 p=0.048͸άOR 4.59 95% CI 2.33 9.06 p<0.01س̶ӳء

    RCSļӦͼƽHbA1c֬ԡϸNAS֮ϵǷԺͽƵĵLߡ۲쵽HbA1c֢֮ΪVμӦߡƽHbA1c<7.0%53 mmol/mol⵽֬ԡϸNASĽأЩصHbA1c7%53 mmol/molʱʧ

    оԱ۲쵽HbA1cά֮Թڹ㷺HbA1cΧڣӴԼ511%3197 mmol/molȻHbA1cNASHĿ֮䣬ԼNASH֯ѧس̶ȣ֬ԡ䣩֮ĹHbA1cˮƽ7%53 mmol/molֲ֮ԭвرǸϸ͸ά֮IJ졣

    ֵעǣ֤ݱϸس̶ǸάԤӡˣѪǿϸس̶Ⱥ͸άڵǿҹ֧T2DǽNAFLD/NASHԤӵ֪ʶ

    ϣNAFLDǵҽѧսڴио½չ

    39רҵҽƱϢƽ̨ ʽѶŻվ    

    йȵĽŻվйǿ2022-09-27ͨйʷƾáģӵзḻӴûĽƽ̨ڽѶҽʴ𡢾ҽҩϢѯȷȣ߽Ϣ¶ȸdz4û

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